Glycosyl compounds
Sigma Aldrich Fine Chemicals Biosciences Sucrose suitable for microbiology, ACS reagent, >=99.0% | 57-50-1 | MFCD00006626 | 1KG
Sucrose suitable for microbiology, ACS reagent, >=99.0% | Purity: >=99.0% (HPLC); >=99.0% | Mol Wt: 342.3 | 57-50-1 | MFCD00006626 | 1KG
Medchemexpress LLC 1-(2-(diethylamino)ethyl)-3-(2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl)thiourea | 688342-78-1 | 99.7% | 428.64 | C23H36N6S | 1MG
D-I03 is a small-molecule selective RAD52 inhibitor used as a research reagent to study RAD52-dependent single-strand annealing and D-loop formation. It shows cellular activity against BRCA1- and BRCA2-deficient cells.
- Selective RAD52 inhibitor with Kd 25.8 μM.
- Inhibits RAD52-dependent single-strand annealing and D-loop formation.
- Cellular activity: suppresses growth of BRCA1- and BRCA2-deficient cells.
- Reported IC50 values: 5 μM (SSA) and 8 μM (D-loop).
- Purity 99.7%.
- Molecular weight 428.64 g/mol; formula C23H36N6S.
- Physical state solid; color off-white to light yellow.
- Solubility in DMSO 50 mg/mL.
Medchemexpress LLC Fulvestrant 3-β-D-Glucuronide | 261506-27-8 | 94.79% | 782.89 | 1 MG
Fulvestrant 3-β-D-Glucuronide is a metabolite derived from Fulvestrant, a pure anti-estrogenic steroid. It is characterized as a glucuronide and sulfate conjugate. This compound is primarily intended for breast cancer research.
- Derived from an anti-estrogenic steroid.
- Exists as glucuronide and sulfate conjugates.
- Applicable in breast cancer research.
- Solid appearance, white to off-white in color.
- High purity of 94.79%.
eMolecules Pharmablock / methyl 4-methoxy-1H-indole-2-carboxylate / 25mg / 731744183 / PBT1594 / 0.000 / 111258-23-2 / MFCD00134300 / 205.213 / C11H11NO3
Pharmablock / methyl 4-methoxy-1H-indole-2-carboxylate / 25mg / 731744183 / PBT1594 / 0.000 / 111258-23-2 / MFCD00134300 / 205.213 / C11H11NO3
Medchemexpress LLC Inosine-15N4 | 204634-01-5 | C10H1215N4O5 | 1 MG
Inosine-15N4 is the 15N labeled Inosine, primarily used as a tracer and internal standard for quantitative analysis in drug development. This compound is valuable for techniques such as NMR, GC-MS, or LC-MS by incorporating stable heavy isotopes into drug molecules.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis
- Incorporates stable heavy isotopes into drug molecules
Medchemexpress LLC Tetrahydrouridine dihydrate | 18771-50-1 | MFCD00063468 | C9H20N2O8 | 5 MG
Tetrahydrouridine dihydrate (THU dihydrate) is a potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. It is intended for research use only.
- Potent inhibitor of cytidine deaminase (CDA)
- Competitively blocks CDA's active site
- More effective than intrinsic cytidine
- Can sensitize some pancreatic and lung carcinoma cells to gemcitabine-induced cell death
- Inhibits s-phase without apoptosis
Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 1 ML
D-64131 is an orally active tubulin inhibitor that demonstrates antimitotic activity by binding to β-tubulin, destabilizing microtubules, and arresting mitotic cells in the M-phase. This compound effectively inhibits the proliferation of tumor cells from various organs and tissues, making it a subject of cancer research.
- Orally active compound
- Inhibits tubulin polymerization
- Exhibits antimitotic effects
- Shows antiproliferative activity against tumor cells
- Effective against multidrug-resistant tumor cell lines
Medchemexpress LLC 2-(5-Phenyl-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)-N-(5-phenylpyridin-2-yl)acetamide | 2074607-48-8 | 99.8% | 432.48 g·mol⁻1 | C26H20N6O | 25 MG
A potent small-molecule Porcn inhibitor for research use that blocks Wnt protein secretion and downstream signaling. It exhibits an EC50 of 80 pM in L-Wnt-STF cells and suppresses phosphorylation of Dvl2/3 and LRP6 in cell-based assays. Supplied as a high-purity solid or as a 10 mM solution in DMSO for experimental convenience.
- Potent Porcn inhibition with an EC50 of 80 pM in L-Wnt-STF cells.
- Blocks secretion of Wnt proteins and downstream signaling pathways.
- Suppresses phosphorylation of Dvl2/3 and LRP6 in cell-based assays.
- High purity (≈99.8%) suitable for biochemical and cellular studies.
- Available as solid quantities (including 25 mg) and as a 10 mM solution in DMSO.
- Recommended storage: solid at 4°C; in solvent at -80°C for long-term stability.
Medchemexpress LLC Galactose 1-phosphate-13C potassium | 478518-78-4 | 98.8% | 337.31 | 10 MG
Galactose 1-phosphate-13C (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt, an intermediate in galactose metabolism and nucleotide sugar. It is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules as tracers for quantitation.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-(-)-Pantolactone | 599-04-2 | 99.96% | 130.14 | 100 G
D-(-)-Pantolactone is an important intermediate used in the synthesis of other active compounds, such as the molluscicide Cyanolide A. It also functions as a calibrant for circular dichroism (CD). Derivatives of D-(-)-Pantolactone have shown good inhibitory activities against FAS and lipid accumulation, making them useful in the research of anti-obesity drugs.
- High purity: 99.96%
- White to off-white solid appearance
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 5 MG
D-64131 is an orally active tubulin inhibitor with an IC50 of 0.53 μM for tubulin polymerization. It has antimitotic activity and can be used for cancer research. It is antimitotic by binding to β-tubulin, which destabilizes microtubules and arrests mitotic cells in the M-phase. It inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM. It is also cytotoxic towards MDR/MRP tumor cell lines. In vivo studies have shown that D-64131 significantly inhibits tumor growth in human amelanoic melanoma MEXF 989 tumor xenograft mice models and exhibits oral bioavailability, being well tolerated at efficacious doses.
- Orally active tubulin inhibitor
- Potent antimitotic activity
- Broad-spectrum anti-tumor activity
- Cytotoxic to drug-resistant cell lines
- Well-tolerated in vivo
- Research use only
- High purity
Medchemexpress LLC α-Lactose | 14641-93-1 | 1 ML
α-Lactose is the major sugar found in milk, existing in two anomeric forms, α and β. The α form typically crystallizes as a monohydrate. As an essential sugar abundant in human and animal milk, it serves as a basic nutrient and a primary substrate for fermentative processes in dairy products like yogurt and kefir. This product is provided with a purity of 98.0% and has a molecular weight of 342.30.
- Major sugar found in milk
- Essential nutrient
- Primary substrate for fermentative processes in dairy products
- Exists in two anomeric forms (α and β)
- α form typically crystallizes as a monohydrate
- Purity: 98.0%
- Molecular weight: 342.30
Medchemexpress LLC [D-Trp34]-Neuropeptide Y | 153549-84-9 | 99.7% | 4311.72 | 5 MG
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist, showing significantly less potency at NPY Y1, Y2, Y4, and y6 receptors. This compound is known to markedly increase food intake in rats.
- Potent and selective NPY Y5 receptor agonist
- Significantly less potent at NPY Y1, Y2, Y4, and y6 receptors
- Increases food intake in rats
- Soluble in water at 100 mg/mL (23.19 mM)
- Appears as a white to off-white solid
Medchemexpress LLC Capsaicin β-D-glucopyranoside | 153409-16-6 | 90.55% | 467.55 | 10 MG
Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor.
- Solid appearance
- White to off-white color
- Molecular formula: C24H37NO8
- Derived from plants, solanaceae, capsicum annuum L.
- Storage as solid at -20°C, sealed, away from moisture and light
- Storage in solvent at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Sapintoxin D | 80998-07-8 | 99.9% | 1 MG
Sapintoxin D is a fluorescent phorbol ester used for studying the activation of protein kinase C (PKC). It acts as a calcium-dependent PKC activator and exhibits antiviral activity against HIV2 ROD, HIV1 3B in MT4 cells, and chikungunya virus in Vero cells. Its molecular weight is 539.62, and its formula is C30H37NO8. It appears as a white to off-white solid and is derived from Plants Euphorbiaceae Shirakiopsis indica (Willd.) Esser. It is intended for research use only.
- Fluorescent phorbol ester
- Utilized for studying the activation of protein kinase C (PKC)
- Calcium-dependent PKC activator
- Demonstrated antiviral activity against HIV2 ROD and HIV1 3B in MT4 cells
- Demonstrated antiviral activity against chikungunya virus in Vero cells
- White to off-white solid appearance
- Derived from Plants Euphorbiaceae Shirakiopsis indica
- For research use only